Mucad 3.6 Full.rarl [BEST]

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Mucad 3.6 Full.rarl

A family of about 50 enzymes with a molecular weight of 21 kDa, distantly related to the alpha subunit of the heterotrimeric G-protein GTPase (EC 3.6.5.1). The most studied of them are three enzymes (GST, GSTT1, GSTP1), which can inhibit (unlike normal liver cells) the activity of the main isoforms of cytochrome P450 (CYP1A2, CYP2C8, CYP2C9, CYP2B6, CYP2C20, CYP3A4, CYP3A5, CYP3A7 and CYP3B7)
in liver cells, which led to the discovery of this family.
These three enzymes are involved in many hepatic drug biotransformation reactions that can have a hepatotoxic effect

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