50 Nijansi Slobodniji.zip 🔆

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50 Nijansi Slobodniji.zip

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Enter your email address to subscribe and receive notifications of new posts by email.Role of epinephrine in the pharmacological prevention of excessive vacuole formation by riluzole in rat liver.
In a recent study on the mechanism of riluzole action we proposed that this drug mediates its activity by activating catecholamine/adrenaline storage mechanisms. To test this hypothesis we studied the effect of a few drugs on vacuole formation in rat liver by light microscopy and the role of epinephrine in the prevention of this process. Vacuole formation appeared to be dose dependent; in 50 mM glucose medium (without electrolytes) vacuoles did not appear in the liver until the daily doses of riluzole exceeded approximately 100 microM. However, when the dose of the drug was decreased to 25 microM there were vacuoles in the hepatocytes although to a lesser extent than in control animals, and thus riluzole-like vacuoles were formed. On the other hand, the addition of epinephrine to the culture medium brought about a dose-dependent reversal of this process (vacuole formation increased from zero at a dose of 0.1 microM, to a maximum value of approximately 14% at a dose of 0.9 microM). The effect of epinephrine was dose-related; it was significant at a concentration of 0.3 microM and maximum at approximately 0.9 microM. This effect is similar to that of riluzole but the effect of both drugs was prevented by propranolol, a catecholamine antagonist. In conclusion, these results suggest that: 1) the induction of vacuoles in the liver is a direct effect of riluzole, and 2) epinephrine can prevent riluzole-induced vacuoles, via an action on its catecholamine storage mechanism.Synopsis

Faye Stevens and her boyfriend are having a camping trip at a deserted lake in the middle of nowhere. Faye is easily frightened and thinks that if a tornado hit it could trap them in a terrifying tunnel while the lake is completely dry. The only person she can actually trust is her boyfriend, but they’re about to make the most important decision of their lives.




A thrilling way to spend a summer

It’s a dull, drizzly Sunday evening, a bit cold out



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